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One such study by Lee et al

(PubMed) Xu J, Patassini S, Begley P, et al

2021 Sep 26;22(1):695

51 The insufficient trial duration and the weakened ability of higher-grade fibrosis to change, secondary to factors like weight loss, are considered the primary reasons for the lack of positive outcomes

In some embodiments, a pH of between about 6.0 and about 7.6, between about 7 and about 7.8, between about 7.0 and about 7.6, between about 7.2 and 7.6, between about 7.2 and about 7.4 is suitable for sterilization (e.g., by filtration or aseptic mixing or heat treatment and/or autoclaving (e.g., terminal sterilization)) of formulations or compositions described herein